Dopamine Receptor Antagonists (DRAs)

DRUGS

PHENOTHIAZINES

• Acetophenazine (Tindal)
• Butaperazine (Repoise)
• Carphenazine (Proketazine)
• Chlorpromazine (Thorazine)
• Fluphenazine (Prolixin/Permitil)
• Mesoridazine (Serentil)
• Perphenazine (Trilafon)
• Piperacetazine (Quide)
• Prochlorperazine (Compazine)
• Promazine (Sparine)
• Thioridazine (Mellaril)
• Trifluoperazine (Stelazine)
• Triflupromazine (Vesprin)

BUTYROPHENONES

• Droperidol (Inapsine)
• Haloperidol (Haldol)

THIOXANTHENES

• Chlorprothixene (Taractan)
• Thiothixene (Navane)

OTHER

• Loxapine (Loxitane)
• Molindone (Moban)
• Pimozide (Orap)
• Reserpine (Diupres)
• Sulpiride (Dogmatil/Sesif)

THERAPEUTIC INDICATIONS

• Schizophrenia
• Schizoaffective Disorder
• Acute Mania
• Depression with psychotic symptoms
• Delusional Disorder
• Borderline Personality Disorder
• Dementia
• Delirium
• Substance-induced Psychotic Disorder
• Tourette's Syndrome
• Huntington's Disease
• Pervasive Developmental Disorder

ADVERSE EFFECTS

• Cardiovascular
• [tachycardiadecreased contractility, orthostatic hypotension, sudden death]
• Gastro-intestinal
• [constipation, dry mouth]
• Neuropsychiatric
• [acute dystonia, akathisia, sedation, tardive dyskinesia, neuroleptic malignant syndrome, acute extrapyramidal effects]