Tricyclic & Tetracyclic Antidepressants (TCAs)

DRUGS

• Amitriptyline (Elavil/Endep)
• Amoxapine (Asendin)
• Clomipramine (Anafranil)
• Desipramine (Norpramin/Pertofran)
• Doxepine (Adapin/Sinequan)
• Imipramine (Tofranil)
• Maprotiline (Ludiomil)
• Nortriptyline (Pamelor/Aventyl)
• Trimipramine (Surmontil)

THERAPEUTIC INDICATIONS

• MDD
• Anxiety Disorders
• PD+AG
• GAD
• OCD
• Pain

ADVERSE EFFECTS

• Cardiovascular
• [tachycardia, orthostatic hypotension, conduction abnormalities]
• Gastro-intestinal
• [constipation, dry mouth]
• Neuropsychiatric
• [sedation, seizures]

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